Wednesday, November 5, 2003
FULL TEXT PAPER
Pregnant Mare's Serum Gonadotropin (PMSG)
by SwineReproNet Staff
This hormone is "pregnant mare's serum gonadotropin". The hormone in the purified form can be found in powder form in PG600 and is available from Chemical or biological supply companies. However, PMSG is not approved for use alone in swine. Produicts labeled as PMSg can be used in swine in serum (non-purified forms). However, the use of non-purified PMSG serum containing products in pigs can cause severe animal health reactions, especially upon adminsitration a second time. Therefore thier use should proceed with extreme caution. The PMSG hormone is produced by the endometrial cups within the pregnant mare uterus. These strcutures produce this hormone to stimulate the mare's ovarian and repsouctive structures. In species other than the horse, PMSG is able to stimulate the ovaries to grow follicles and ovulate these. The hormone has a 3-5 day half-life of biological activity in most species due to its sugrar molecules which reduce clearance of the hormone. This extended biological activity ensures ovarian stimulation and ovulation. However, PMSG use alone often causes cystic ovarian disease beacuse of the unrestrained ovarian stimulation over the 3-5 days of activity.
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